5 edition of Steroid receptors and hormone-dependent neoplasia found in the catalog.
Includes bibliographical references and index.
|Statement||edited by James L. Wittliff and Otto Dapunt.|
|Contributions||Wittliff, James L., Dapunt, Otto.|
|LC Classifications||QP572.S7 I55 1978|
|The Physical Object|
|Pagination||xiv, 301 p. :|
|Number of Pages||301|
|LC Control Number||80080877|
Identification of interaction domains on the classical steroid receptors involved in the rapid effects, and separation of this function from the genomic action of these receptors, should pave the way to a better understanding of the rapid action of steroid hormones (Cato et Cited by: 6. Suggested Citation:"Appendix A: Female Methods." Institute of Medicine. Contraceptive Research and Development: Looking to the Future. Washington, DC: The National Academies Press. doi: / The advent of modern molecular and cell biology has permitted a detailed look at the.
Abstract: More than 70% of all breast cancer cases are estrogen receptor alpha-positive (ERα). ERα is a member of the nuclear receptor family, and its activity is implicated in the gene transcription linked to the proliferation of breast cancer cells, as well as in extranuclear signaling pathways related to the development of resistance to endocrine by: 1. The book starts by describing physiological and pathophysiological roles of steroids, with reference to production and action of gonadal steroids, role of steroid sulfonation, sex specific and steroids-dependent mechanism of hippocampal function, and the hydroxysteroid dehydrogenases for the modulation of tissue glucocorticoid availability.
Get this from a library! Steroid Hormone Action and Cancer. [K M J Menon; Jerry R Reel] -- This volume is an outgrowth of a symposium held at the University of Michigan, Ann Arbor, Michigan, October , This symposium was organized to bring together basic scientists and clinicians. Another important discovery in the immunophilin field related to the endocrine mechanism of action of steroid receptors was the hormone-dependent biological activity of the receptors, which is itself affected by the type of immunophilin present in the complex. Neoplasia , 10, – [Google Scholar]Cited by: 5.
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Steroid receptors and hormone-dependent neoplasia. New York: Masson Pub. USA, © (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: James L Wittliff; Otto Dapunt.
Ovarian Steroid Hormones and Breast Cancer. Removal of the ovaries was recognized as an effective treatment for breast cancer in the late 19th century [1, 2].It is now well established that three quarters of breast cancers are hormone dependent, requiring local or systemic estrogens for growth by: Targeting steroid hormone receptor pathways in the treatment of hormone dependent cancers.
Ko YJ(1), Balk SP. Author information: (1)Cancer Biology Program, Hematology-Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Brookline Avenue, Boston, MA Cited by: The ovarian hormones progesterone and estrogen play important roles in breast cancer etiology, proliferation, and treatment.
Androgens may also contribute to breast cancer risk and progression. In recent years, significant advances have been made in defining the roles of these steroid hormones in stem cell homeostasis in the breast.
Stem cells are potential origins of breast cancer and Cited by: Predictive role of steroid receptors in evaluating the response to endocrine therapy J. and Dapunt, O. (eds.) Steroid Receptors and Hormone-dependent Neoplasia. – (New York: Masson Publishing Predictive role of steroid receptors in evaluating the response to endocrine therapy.
In: Ghanadian R. (eds) The Endocrinology of Author: R. Ghanadian. The transcriptional program of a cell is shaped by its transcription factor (TF) repertoire and its genetic makeup.
We summarize molecular mechanisms involved in creating steroid receptor–driven gene expression programs in hormone-dependent cancers and will elucidate the interplay between steroid receptor–dependent transcription and genetic alterations that contribute to Cited by: This chapter reviews what is known about the mechanisms of steroid action.
The classic mode of action entails simple diffusion of steroid hormones into the cell, where they interact with cognate receptors and stimulate or inhibit transcription of target genes (). 3 The hormone-dependent changes in receptor conformation drive transactivation and transrepression of gene expression by altering Cited by: 3.
G.V. Sherbet, in Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy, Publisher Summary. Androgen receptor is a member of the steroid and nuclear hormone receptor family, which includes glucocorticoid and mineralocorticoid receptors, ER, PR, and the vitamin D3 receptor.
The activation of androgen receptor (AR), a nuclear transcription factor, begins with. Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone humans, ERα is encoded by the gene ESR1 (EStrogen Receptor 1).Aliases: ESR1, ER, ESR, ESRA, ESTRR, Era.
The half-life of steroid hormone receptors ranges from 2–4 h for ERαand 4 h for AR, to 7–10 h for PR and 19 h for GR. The relatively long half-life of the steroid hormone receptors strongly suggests that the receptor proteins are recycled before eventual degradation. Steroids, thyroid hormones, vitamin D3, and retinoids are lipophilic small molecules that regulate diverse biological effects such as cell differentiation, development, and homeostasis.
The actions of these hormones are mediated by steroid/nuclear receptors which function as ligand-dependent transcriptional regulators. Transcriptional activation by ligand-bound receptors is a complex process Cited by: Lippman M: Glucocorticoid receptors in human leukemia, in Witliff JL, & Dapunt O (eds): Steroid Receptors and Hormone-Dependent Neoplasia.
New York: Masson,pp – Lippman M: Glucocorticoid receptors in human leukemia, in Witliff JL, Dapunt O (eds): Steroid Receptors and Hormone-Dependent Neoplasia. New York: Masson,pp Cited by: Abstract: Sex steroid hormones play a central role in the development and progression of prostate and breast cancers.
The biological functions of these and other steroid hormones are mediated by a family of closely related steroid hormone receptors (SHRs), with the androgen receptor (AR) mediating the effects of testosterone and related androgens, and the classical estrogen receptor (ERα Cited by: Steroid Hormone Receptor Expression in Nasopharyngeal Angiofibromas Article (PDF Available) in American Journal of Clinical Pathology (6) July with Reads How we measure 'reads'.
Extensive research over the past 25 years in hormone-dependent cancers, such as breast cancer and prostate cancer, has identified the molecular mechanisms driven by steroid receptors, elucidating the interplay between genomic and non-genomic steroid receptors mechanism of action.
Altogether, these mechanisms create the specific gene expression programs that contribute to endocrine therapy Cited by: 4. Hormone-dependent phosphorylation of steroid hormone receptors may play an important role in binding of the receptor to its specific response element on the gene and subsequent activation of transcription.
PR, GR, ERα, and VDR are all phosphorylated after binding to their respective ligands. Sex steroid hormones, estrogen, progesterone and androgen, play pivotal roles in sex differentiation and development, and in reproductive functions and sexual behavior.
Studies have shown that sex steroid hormones are the key regulators in the development and progression of endocrine-related cancers, especially the cancers of the reproductive by: Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors.
Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock proteins, and translocates to the nucleus.
Mechanism of Action: Hormones with Intracellular Receptors. Receptors for steroid and thyroid hormones are located inside target cells, in the cytoplasm or nucleus, and function as ligand-dependent transcription is to say, the hormone-receptor complex binds to promoter regions of responsive genes and stimulate or sometimes inhibit transcription from those genes.
Steroid receptors in human breast cancer Article Literature Review in Trends in Endocrinology and Metabolism 15(7) October with 30 Reads How we measure 'reads'. The importance of steroid hormones in breast cancer has been known for decades, and many studies have described the ontogeny of steroid receptor expression in both rodent model systems and the human mammary gland.
5,6 The ER exists as two isoforms, ERα and ERβ, which are encoded by two different genes ().Like other steroid receptors, the ER has a structure consisting of a DNA Cited by: Oestrogens, Xenoestrogens and Hormone-Dependent Cancers. By Anna Ptak and Ewa Lucja Gregoraszczuk.
Submitted: November 24th Reviewed: October 17th Published: January 23rd DOI: /Author: Anna Ptak, Ewa Lucja Gregoraszczuk.This volume is an outgrowth of a symposium held at the University of Michigan, Ann Arbor, Michigan, OctoberThis symposium was organized to bring together basic scientists and clinicians for the purpose of exchanging new ideas and the latest information in the area of Steroid Hormone.